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Contextualizing selection bias in Mendelian randomization: how bad is it likely to be?

Published 30 September 2019 Selection bias affects Mendelian randomization investigations when selection into the study sample depends on a collider between the genetic variant and confounders of the risk factor–outcome association. However, the relative importance of selection bias for Mendelian randomization compared with other potential biases is unclear. New publication in International Journa

https://www.lupop.lu.se/article/contextualizing-selection-bias-mendelian-randomization-how-bad-it-likely-be - 2025-01-10

Barriers and Opportunities for Use of Patient Registries in Medicines Regulation

Published 2 October 2019 The European Medicines Agency (EMA) established the Patient Registry Initiative to explore ways of supporting the use of patient registries in generating high-quality data for regulatory decision making and to enable a systematic approach to their use. We review barriers and opportunities for using patient registries in medicines regulation. A key aspect is that early disc

https://www.lupop.lu.se/article/barriers-and-opportunities-use-patient-registries-medicines-regulation - 2025-01-10

Bayesian Methods for Exposure Misclassification Adjustment in a Mediation Analysis

Published 3 October 2019 Soil-transmitted helminth infections have been found to be associated with child development. The objective was to investigate hemoglobin levels and malnutrition as mediators of the association between Ascaris infection and intelligence quotient (IQ) scores in children. New publication in Epidemiology.Read more here.

https://www.lupop.lu.se/article/bayesian-methods-exposure-misclassification-adjustment-mediation-analysis - 2025-01-10

The what, when and how of orthopaedic registers: an introduction into register-based research

Published 4 October 2019 Establishment of orthopaedic registers started in 1975 and many registers have been initiated since. The main purpose of registers is to collect information on patients, implants and procedures in order to monitor and improve the outcome of the specific procedure. New publicatoin in Efort.Read more here

https://www.lupop.lu.se/article/what-when-and-how-orthopaedic-registers-introduction-register-based-research-0 - 2025-01-10

Echocardiographic Findings in Patients with Mild to Moderate Chronic Kidney Disease without Symptomatic Heart Failure

Published 1 November 2019 A significant association between mild to moderate impairment of renal function and echocardiographic markers of cardiac structure and diastolic function was observed, supporting the hypothesis that interaction between the kidney and heart exists even in the early stages of renal impairment. Read the full paper here.

https://www.lupop.lu.se/article/echocardiographic-findings-patients-mild-moderate-chronic-kidney-disease-without-symptomatic-heart - 2025-01-10

Demographic and diagnostic profiles of older people with intellectual disability and prescription of antipsychotics

Published 11 October 2019 Older people with ID may be prescribed antipsychotic medication without thorough psychiatric diagnosing. Thus, there is a need for improving the abilities of health care professionals to properly diagnose and manage psychiatric illness in this population. Read the full paper here.

https://www.lupop.lu.se/article/demographic-and-diagnostic-profiles-older-people-intellectual-disability-and-prescription - 2025-01-10